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Article

Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017

Shaw Jacqueline A, Guttery David S, Hills Allison, Fernandez-Garcia Daniel, Page Karen, Rosales Brenda M, Goddard Kate S, Hastings Robert K, Luo Jinli, Ogle Olivia, Woodley Laura, Ali Simak, Stebbing Justin, Coombes R Charles

Abstract excerpt

PURPOSE: The purpose of this study was to directly compare mutation profiles in multiple single circulating tumor cells (CTC) and cell-free DNA (cfDNA) isolated from the same blood samples taken from patients with metastatic breast cancer (MBC). We aimed to determine whether cfDNA would reflect the heterogeneity observed in 40 single CTCs. EXPERIMENTAL DESIGN: CTCs were enumerated by CELLSEARCH. CTC count was...

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Source

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Identifiers

PMID: 27334837
DOI: 10.1158/1078-0432.CCR-16-0825
PMCID: PMC6241844

Genes

ESR1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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