Article

Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune response

2026-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Lung is a major site of metastases for many primary cancers associated with poor outcomes. A central challenge in cancer immunotherapy is overcoming tumor immune evasion, which limits effective antitumor responses. Here, we investigated whether combinatorial mRNA-encoded cytokine therapy can overcome tumor immune evasion by coordinately engaging innate and adaptive immunity, using murine models...

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Literature Corpus work: a14e9c1d-ed44-50a1-8850-732c0aa72e39
DOI: 10.64898/2026.05.06.723126

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