Article
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
The Journal of clinical investigation - 3 Aug 2020
Cochrane Catherine R, Vaghjiani Vijesh, Szczepny Anette, Jayasekara W Samantha N, Gonzalez-Rajal Alvaro, Kikuchi Kazu, McCaughan Geoffrey W, Burgess Andrew, Gough Daniel J, Watkins D Neil, Cain Jason E
Abstract excerpt
Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh pathway activation in adult solid tumors, such as small-cell lung cancer (SCLC), is unknown. Here we show that combined inactivation of Trp53 and Rb1, a defining genetic feature of SCLC, leads to hypersensitivity to Hh ligand in vitro, and during neural tube...
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