Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

20 Nov 2017

Abstract excerpt

Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain carcinomas depends on a small subset of tumor cells, called "tumor-initiating cells" (TICs), with SC-like properties. Mammary SCs (MaSCs) reside in the basal compartment of the mammary epithelium, and their neoplastic counterparts,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Genetic and Kidney Cyst Diseases
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29158396
DOI: 10.1073/pnas.1711534114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signalingPMID 29158396Read ↗

Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells: From Molecular Anatomy to Molecular PathwaySemantic proximity Read ↗

Primary Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling PathwaysSemantic proximity Read ↗

Basal cells as stem cells of the mouse trachea and human airway epitheliumSemantic proximity Read ↗

Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapySemantic proximity Read ↗

The primary cilium as a Hedgehog signal transduction machine.Semantic proximity Read ↗

Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.Semantic proximity Read ↗

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

Loss of primary cilia occurs early in breast cancer developmentSemantic proximity Read ↗

A changing signaling environment induces multiciliated cell trans-differentiation during developmental remodelingSemantic proximity Read ↗

Signaling Control of Mucociliary Epithelia: Stem Cells, Cell Fates, and the Plasticity of Cell Identity in Development and DiseaseSemantic proximity Read ↗

EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives therapeutic resistance and is a druggable vulnerability in triple-negative breast cancerSemantic proximity Read ↗

Understanding cancer cell plasticity: EMT, respecialisation, and therapeutic opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.