Article
EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.
Scientific reports - 1 Jan 2012
Bornachea Olga, Santos Mirentxu, Martínez-Cruz Ana Belén, García-Escudero Ramón, Dueñas Marta, Costa Clotilde, Segrelles Carmen, Lorz Corina, Buitrago Agueda, Saiz-Ladera Cristina, Agirre Xabier, Grande Teresa, Paradela Beatriz, Maraver Antonio, Ariza José M, Prosper Felipe, Serrano Manuel, Sánchez-Céspedes Montse, Paramio Jesús M
Abstract excerpt
Missense mutations in TP53 gene promote metastasis in human tumours. However, little is known about the complete loss of function of p53 in tumour metastasis. Here we show that squamous cell carcinomas generated by the specific ablation of Trp53 gene in mouse epidermis are highly metastatic. Biochemical and genome-wide mRNA and miRNA analyses demonstrated that metastases are associated with the early induction of...
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