Article

Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines

2022-03-22

Abstract excerpt

Dysfunction of the primary cilium, a microtubule-based signaling organelle, leads to genetic conditions called ciliopathies. Hedgehog (Hh) signaling is mediated by the primary cilium in vertebrates and is therefore implicated in ciliopathies; however, it is not clear which immortal cell lines are the most appropriate for modeling pathway response in human disease; therefore we systematically evaluated Hh in five c...

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Literature Corpus work: 88078aaa-b5e3-52fb-a5cd-cb96fbc77fd4
DOI: 10.1101/2022.03.22.485292

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