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Article

GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor development

11 Jul 2018

Abstract excerpt

GPRC5A, a retinoic acid induced gene, is preferentially expressed in lung tissue. Gprc5a gene deletion leads to spontaneous lung tumor development. However, the mechanism of Gprc5a-mediated lung tumor suppression is not fully understood. Here we showed that MDM2, a p53-negative regulator, was dysregulated in Gprc5a-knockout (ko) mouse tracheal epithelial cells (KO-MTEC) compared to wild type ones. Targeting MDM2...

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PMID: 29992578
DOI: 10.1002/ijc.31726

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