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Article

FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells.

Nucleic acids research - 16 Feb 2018

Pentzold Constanze, Shah Shiraz Ali, Hansen Niels Richard, Le Tallec Benoît, Seguin-Orlando Andaine, Debatisse Michelle, Lisby Michael, Oestergaard Vibe H

Abstract excerpt

Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer cells. Orthologs of human CFSs are found in a number of other mammals, but the extent of CFS conservation beyond the...

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Source

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Identifiers

PMID: 29253234
DOI: 10.1093/nar/gkx1260
PMCID: PMC5815096

Genes

FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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