Genetic Contribution to Metastatic Prostate Cancer.

doi:10.1016/j.ucl.2021.03.005

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Article

Genetic Contribution to Metastatic Prostate Cancer.

The Urologic clinics of North America - 1 Aug 2021

Sokolova Alexandra O, Obeid Elias I, Cheng Heather H

Abstract excerpt

Recent studies show that the prevalence of germline pathogenic and likely pathogenic variants (also known as mutations) in DNA repair genes in metastatic prostate cancer is higher than previously recognized and higher than in unaffected men. Specific gene dysfunction is important in prostate cancer initiation and/or evolution to metastases. This article reviews key literature on individual genes, recognizing...

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PMID: 34210490
DOI: 10.1016/j.ucl.2021.03.005

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