Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Emerging Landscape for Canonical and Actionable Molecular Alterations in Primary and Metastatic Prostate Cancer.

Molecular cancer therapeutics - 1 Jun 2020

Dawson Nancy A, Zibelman Matthew, Lindsay Timothy, Feldman Rebecca A, Saul Michelle, Gatalica Zoran, Korn W Michael, Heath Elisabeth I

Abstract excerpt

Patients with prostate cancer with tumors harboring defects in DNA-repair genes (DRD) generally do not respond well to AR-directed therapy. Furthermore, canonical pathways evolve during disease progression and may affect treatment with existing therapies. Due to the limited treatment options after failure of hormonal and taxane therapy, and the tumor heterogeneity induced by DRD, we sought to characterize the...

Topics

Join the communities discussing this publication.

Aged, 80 and over
Biomarkers, Tumor
Gene Expression Regulation, Neoplastic
Genomics
Microsatellite Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Prostatic Neoplasms

Source

Identifiers

PMID: 32220973
DOI: 10.1158/1535-7163.MCT-19-0531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Emerging Landscape for Canonical and Actionable Molecular Alterations in Primary and Metastatic Prostate Cancer.PMID 32220973Read ↗

An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKTSemantic proximity Read ↗

Impact of DNA damage repair alterations on prostate cancer progression and metastasisSemantic proximity Read ↗

Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancerSemantic proximity Read ↗

Prognostic and therapeutic implications of DNA repair gene mutations in advanced prostate cancer.Semantic proximity Read ↗

Germline and somatic DNA repair gene alterations in prostate cancer.Semantic proximity Read ↗

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision MakingSemantic proximity Read ↗

DNA Damage Response and Mismatch Repair Gene Defects in Advanced and Metastatic Prostate CancerSemantic proximity Read ↗

Clinical implications of genomic alterations in metastatic prostate cancer.Semantic proximity Read ↗

BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.Semantic proximity Read ↗

Genomics of lethal prostate cancer at diagnosis and castration resistanceSemantic proximity Read ↗

Integrative clinical genomics of advanced prostate cancer.Semantic proximity Read ↗

The Molecular Taxonomy of Primary Prostate Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.