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Prevalence and clinical impact of tumor BRCA1 and BRCA2 mutations in patients presenting with localized or metastatic hormone-sensitive prostate cancer.

Prostate cancer and prostatic diseases - 1 Feb 2022

Martinez Chanza Nieves, Bernard Brandon, Barthelemy Philippe, Accarain Anna, Paesmans Marianne, Desmyter Laurence, T'Kint de Roodenbeke Daphne, Gil Thierry, Sideris Spyridon, Roumeguere Thierry, Hamid Anis A, Sweeney Christopher J

Abstract excerpt

BACKGROUND: The appropriate management of localized or metastatic hormone-sensitive prostate cancer (HSPC) patients harboring tumor BRCA mutations (tBRCAm) is not well-characterized. We sought to evaluate the prevalence and clinical outcomes of patients with tBRCAm and localized or de novo metastatic HSPC. METHODS: We performed a multicenter, international, retrospective cohort study of localized (cohort 1) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34108647
DOI: 10.1038/s41391-021-00397-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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