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Article

Genome-scale deconvolution of RNA structure ensembles.

Nature methods - 1 Mar 2021

Morandi Edoardo, Manfredonia Ilaria, Simon Lisa M, Anselmi Francesca, van Hemert Martijn J, Oliviero Salvatore, Incarnato Danny

Abstract excerpt

RNA structure heterogeneity is a major challenge when querying RNA structures with chemical probing. We introduce DRACO, an algorithm for the deconvolution of coexisting RNA conformations from mutational profiling experiments. Analysis of the SARS-CoV-2 genome using dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq) and DRACO, identifies multiple regions that fold into two mutually exclusive...

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PMID: 33619392
DOI: 10.1038/s41592-021-01075-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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