Article
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype.
Leukemia - 1 Mar 2021
Marçais Ambroise, Lhermitte Ludovic, Artesi Maria, Laurent Cécile, Durkin Keith, Hahaut Vincent, Rosewick Nicolas, Suarez Felipe, Sibon David, Cheminant Morgane, Avettand-Fenoel Veronique, Bruneau Julie, Georges Michel, Pique Claudine, Van den Broeke Anne, Asnafi Vahid, Hermine Olivier
Abstract excerpt
Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes. We performed targeted deep sequencing combined with mapping of HTLV-1 proviral integration sites of 61 ATL patients of African and Caribbean origin. This revealed mutations mainly affecting TCR/NF-kB (74%), T-cell trafficking (46%), immune escape (29%), and cell cycle (26%) related pathways, consistent with the genomic...
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