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Article

Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma.

Neoplasia (New York, N.Y.) - 1 Sept 2018

Farmanbar Amir, Firouzi Sanaz, Makałowski Wojciech, Kneller Robert, Iwanaga Masako, Utsunomiya Atae, Nakai Kenta, Watanabe Toshiki

Abstract excerpt

The clonal architecture of tumors plays a vital role in their pathogenesis and invasiveness; however, it is not yet clear how this clonality contributes to different malignancies. In this study we sought to address mutational intratumor heterogeneity (ITH) in adult T-cell leukemia/lymphoma (ATL). ATL is a malignancy with an incompletely understood molecular pathogenesis caused by infection with human T-cell...

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Source

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Identifiers

PMID: 30032036
DOI: 10.1016/j.neo.2018.07.001
PMCID: PMC6074008

Genes

CARD11
CCR4
NOTCH1
PLCG1

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