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Article

Structural Basis of p75 Transmembrane Domain Dimerization.

The Journal of biological chemistry - 3 Jun 2016

Nadezhdin Kirill D, García-Carpio Irmina, Goncharuk Sergey A, Mineev Konstantin S, Arseniev Alexander S, Vilar Marçal

Abstract excerpt

Dimerization of single span transmembrane receptors underlies their mechanism of activation. p75 neurotrophin receptor plays an important role in the nervous system, but the understanding of p75 activation mechanism is still incomplete. The transmembrane (TM) domain of p75 stabilizes the receptor dimers through a disulfide bond, essential for the NGF signaling. Here we solved by NMR the three-dimensional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27056327
DOI: 10.1074/jbc.M116.723585
PMCID: PMC4933281

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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