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Article

Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2010

Xie Pingxing, Kranzler Henry R, Poling James, Stein Murray B, Anton Raymond F, Farrer Lindsay A, Gelernter Joel

Abstract excerpt

FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid receptor. Polymorphisms at the FKBP5 locus have been associated with increased recurrence risk of depressive episodes and rapid response to antidepressant treatment. A recent study showed that FKBP5 genotypes moderated the risk of post-traumatic stress disorder (PTSD) symptoms associated with childhood maltreatment. One...

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Identifiers

PMID: 20393453
DOI: 10.1038/npp.2010.37
PMCID: PMC2946626

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.PMID 20393453Read ↗

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