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Article

Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders.

International journal of molecular sciences - 25 Jan 2024

Großmann Nora L, Weihs Antoine, Kühn Luise, Sauer Susann, Röh Simone, Wiechmann Tobias, Rex-Haffner Monika, Völzke Henry, Völker Uwe, Binder Elisabeth B, Teumer Alexander, Homuth Georg, Klinger-König Johanna, Grabe Hans J

Abstract excerpt

Childhood maltreatment is an important risk factor for adult depression and has been associated with changes in the hypothalamic pituitary adrenal (HPA) axis, including cortisol secretion and methylation of the FKBP5 gene. Furthermore, associations between depression and HPA changes have been reported. This study investigated the associations of whole-blood FKBP5 mRNA levels, serum cortisol levels, childhood...

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Identifiers

PMID: 38338761
DOI: 10.3390/ijms25031485
PMCID: PMC10855893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders.PMID 38338761Read ↗

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Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population.Semantic proximity Read ↗

Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated childrenSemantic proximity Read ↗

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