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Article

Individual and joint contributions of genetic and methylation risk scores for enhancing lung cancer risk stratification: data from a population-based cohort in Germany.

Clinical epigenetics - 18 Jun 2020

Yu Haixin, Raut Janhavi R, Schöttker Ben, Holleczek Bernd, Zhang Yan, Brenner Hermann

Abstract excerpt

BACKGROUND: Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional consideration of genetic risk scores (GRSs) and epigenetic risk scores defined by DNA methylation. METHODS: We conducted a nested case-control study of 143 incident LC cases and 1460 LC-free controls...

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Identifiers

PMID: 32552915
DOI: 10.1186/s13148-020-00872-y
PMCID: PMC7301507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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