Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification.

doi:10.1002/ijc.70316

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Article

Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification.

International journal of cancer - 1 Jun 2026

Hafeez Khadija Sana, Debernardi Carla, Allione Alessandra, Herman Elton Jalis, Guarrera Simonetta, Ferrante Daniela, Aspesi Anna, Sculco Marika, La Vecchia Marta, Sacerdote Carlotta, Grosso Federica, Lill Christina M, Masala Giovanna, Guevara Marcela, Schulze Matthias B, Panico Salvatore, Asgari Yaszan, Park Seehyun, Tagliabue Giovanna, Tjønneland Anne, Agudo Antonio, Weiderpass Elisabete, Magnani Corrado, Dianzani Irma, Vineis Paolo, Casalone Elisabetta, Matullo Giuseppe

Abstract excerpt

Pleural mesothelioma (PM) is a lethal cancer primarily caused by asbestos exposure. Not all exposed individuals develop PM, suggesting the involvement of additional factors. This underscores the need for robust predictive models integrating biomarkers from multi-omic domains to improve risk stratification and early detection. We developed and evaluated polygenic risk scores (PRS) and methylation risk scores (MRS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

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Identifiers

PMID: 41472358
DOI: 10.1002/ijc.70316
PMCID: PMC13047241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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