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Article

RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.

Science translational medicine - 8 Nov 2017

Ito Daisuke, Hatano Mami, Suzuki Norihiro

Abstract excerpt

Advanced genetic approaches have accelerated the identification of causative genes linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Most of the disease-related proteins encoded by these genes form aggregates in the cellular machineries that regulate RNA and protein quality control in cells. Cross-talk among the signaling pathways governing these...

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PMID: 29118263
DOI: 10.1126/scitranslmed.aah5436

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