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Article

The human immunodeficiency virus type 1 ribosomal frameshifting site is an invariant sequence determinant and an important target for antiviral therapy.

Journal of virology - 1 Feb 2004

Biswas Preetha, Jiang Xi, Pacchia Annmarie L, Dougherty Joseph P, Peltz Stuart W

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) utilizes a distinctive form of gene regulation as part of its life cycle, termed programmed -1 ribosomal frameshifting, to produce the required ratio of the Gag and Gag-Pol polyproteins. We carried out a sequence comparison of 1,000 HIV-1 sequences at the slippery site (UUUUUUA) and found that the site is invariant, which is somewhat surprising for a virus known for its...

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Identifiers

PMID: 14747573
DOI: 10.1128/jvi.78.4.2082-2087.2004
PMCID: PMC369415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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