Article
A review on architecture of the gag-pol ribosomal frameshifting RNA in human immunodeficiency virus: a variability survey of virus genotypes.
Journal of biomolecular structure & dynamics - 1 Jun 2017
Qiao Qi, Yan Yanhua, Guo Jinmei, Du Shuqiang, Zhang Jiangtao, Jia Ruyue, Ren Haimin, Qiao Yuanbiao, Li Qingshan
Abstract excerpt
Programmed '-1' ribosomal frameshifting is necessary for expressing the pol gene overlapped from a gag of human immunodeficiency virus. A viral RNA structure that requires base pairing across the overlapping sequence region suggests a mechanism of regulating ribosome and helicase traffic during expression. To get precise roles of an element around the frameshift site, a review on architecture of the frameshifting...
Topics
- Base Pairing
- Base Sequence
- Frameshifting, Ribosomal
- Gene Expression Regulation, Viral
- Genes, Overlapping
- Genes, gag
- Genes, pol
- Genotype
- HEK293 Cells
- HIV-1
- Humans
- Nucleic Acid Conformation
- RNA Helicases