Article
Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2020
Swerdlow Russell H, Hui Dongwei, Chalise Prabhakar, Sharma Palash, Wang Xinkun, Andrews Shea J, Pa Judy, Mahnken Jonathan D, Morris Jill, Wilkins Heather M, Burns Jeffrey M, Michaelis Mary L, Michaelis Elias K
Abstract excerpt
INTRODUCTION: Inherited mitochondrial DNA (mtDNA) variants may influence Alzheimer's disease (AD) risk. METHODS: We sequenced mtDNA from 146 AD and 265 cognitively normal (CN) subjects from the University of Kansas AD Center (KUADC) and assigned haplogroups. We further considered 244 AD and 242 CN AD Neuroimaging Initiative (ADNI) subjects with equivalent data. RESULTS: Without applying multiple comparisons...
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