Article
Do haplogroups H and U act to increase the penetrance of Alzheimer's disease?
Cellular and molecular neurobiology - 1 May 2007
Fesahat Farzaneh, Houshmand Massoud, Panahi Mehdi Shafa Shariat, Gharagozli Kurosh, Mirzajani Farzaneh
Abstract excerpt
1. Alzheimer's disease (AD) is the most common form of dementia in the elderly in which interplay between genes and the environment is supposed to be involved. Mitochondrial DNA (mtDNA) has the only noncoding regions at the displacement loop (D-loop) region that contains two hypervariable segments (HVS-I and HVS-II) with high polymorphism. mtDNA has already been fully sequenced and many subsequent publications...
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