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Article

Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Tranah Gregory J, Nalls Michael A, Katzman Shana M, Yokoyama Jennifer S, Lam Ernest T, Zhao Yiqiang, Mooney Sean, Thomas Fridtjof, Newman Anne B, Liu Yongmei, Cummings Steven R, Harris Tamara B, Yaffe Kristine

Abstract excerpt

Mitochondrial dysfunction is a prominent hallmark of Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) damage may be a major cause of abnormal reactive oxidative species production in AD or increased neuronal susceptibility to oxidative injury during aging. The purpose of this study was to assess the influence of mtDNA sequence variation on clinically significant cognitive impairment and dementia risk in the...

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Identifiers

PMID: 22785396
DOI: 10.3233/JAD-2012-120466
PMCID: PMC4156011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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