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Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans.

Neurobiology of aging - 1 Feb 2014

Tranah Gregory J, Yokoyama Jennifer S, Katzman Shana M, Nalls Michael A, Newman Anne B, Harris Tamara B, Cesari Matteo, Manini Todd M, Schork Nicholas J, Cummings Steven R, Liu Yongmei, Yaffe Kristine

Abstract excerpt

Mitochondrial dysfunction occurs early in the course of several neurodegenerative diseases, and is potentially related to increased oxidative damage and amyloid-β (Aβ) formation in Alzheimer's disease. The goals of this study were to assess mtDNA sequence associations with dementia risk, 10-year cognitive change, and markers of oxidative stress and Aβ among 1089 African-Americans in the population-based Health,...

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Source

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Identifiers

PMID: 24140124
DOI: 10.1016/j.neurobiolaging.2013.05.023
PMCID: PMC4019378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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