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Article

Mitochondrial genomic analysis of late onset Alzheimer's disease reveals protective haplogroups H6A1A/H6A1B: the Cache County Study on Memory in Aging.

PloS one - 1 Jan 2012

Ridge Perry G, Maxwell Taylor J, Corcoran Christopher D, Norton Maria C, Tschanz Joann T, O'Brien Elizabeth, Kerber Richard A, Cawthon Richard M, Munger Ronald G, Kauwe John S K

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia and AD risk clusters within families. Part of the familial aggregation of AD is accounted for by excess maternal vs. paternal inheritance, a pattern consistent with mitochondrial inheritance. The role of specific mitochondrial DNA (mtDNA) variants and haplogroups in AD risk is uncertain. METHODOLOGY/PRINCIPAL FINDINGS: We determined the...

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PMID: 23028804
DOI: 10.1371/journal.pone.0045134
PMCID: PMC3444479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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