Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.

doi:10.1016/j.ccell.2019.10.008

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Article

Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.

Cancer cell - 9 Dec 2019

Leruste Amaury, Tosello Jimena, Ramos Rodrigo Nalio, Tauziède-Espariat Arnault, Brohard Solène, Han Zhi-Yan, Beccaria Kevin, Andrianteranagna Mamy, Caudana Pamela, Nikolic Jovan, Chauvin Céline, Niborski Leticia Laura, Manriquez Valeria, Richer Wilfrid, Masliah-Planchon Julien, Grossetête-Lalami Sandrine, Bohec Mylene, Lameiras Sonia, Baulande Sylvain, Pouponnot Celio, Coulomb Aurore, Galmiche Louise, Surdez Didier, Servant Nicolas, Helft Julie, Sedlik Christine, Puget Stéphanie, Benaroch Philippe, Delattre Olivier, Waterfall Joshua J, Piaggio Eliane, Bourdeaut Franck

Abstract excerpt

Rhabdoid tumors (RTs) are genomically simple pediatric cancers driven by the biallelic inactivation of SMARCB1, leading to SWI/SNF chromatin remodeler complex deficiency. Comprehensive evaluation of the immune infiltrates of human and mice RTs, including immunohistochemistry, bulk RNA sequencing and DNA methylation profiling studies showed a high rate of tumors infiltrated by T and myeloid cells. Single-cell RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31708437
DOI: 10.1016/j.ccell.2019.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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