Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy.

doi:10.1016/j.medj.2026.101266

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Article

Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy.

Med (New York, N.Y.) - 11 Sept 2026

Knight Andrew D, Robitschek Emily J, Lin Jia-Ren, Aprati Tyler, Tarantino Giuseppe, Chen Jaijia, Frederick Dennie T, Shi Alvin, Larque Ana B, Miao Benchun, Raghavan Rumya S, Sharova Tatyana, Shin John H, Sorger Peter, Kellis Manolis, Flaherty Keith T, Hacohen Nir, Boland Genevieve M, Chebib Ivan, Liu David, Sullivan Ryan J, Mehta Arnav

Abstract excerpt

BACKGROUND: Acquired resistance to immune checkpoint inhibitors (ICIs) remains a significant challenge in the treatment of metastatic melanoma. Phenotypic plasticity, such as dedifferentiation and transdifferentiation, is an increasingly recognized mechanism of treatment resistance. METHODS: We present a case of a 70-year-old man with metastatic melanoma who experienced progression through sequential treatments...

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Topics

Humans
Male
Aged
Rhabdomyosarcoma
Melanoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Immunotherapy

Antibodies, Monoclonal, Humanized

Immune Checkpoint Inhibitors

Drug Resistance, Neoplasm

Ipilimumab

Exome Sequencing

Mutation

Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 42624103
DOI: 10.1016/j.medj.2026.101266

Genes

CD163
NF1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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