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Tumour heterogeneity and immune-modulation

7 May 2013

Abstract excerpt

Recent advances in sequencing technologies have revealed extensive intratumour heterogeneity (ITH) both within individual tumours and between primary and metastatic tumours for different cancer types. Such genetic diversity may have clinical implications for both cancer diagnosis and treatment with increasing evidence linking ITH and therapeutic resistance. Nonetheless, whilst limiting the activity of targeted...

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Identifiers

PMID: 23664091
DOI: 10.1016/j.coph.2013.04.006

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