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Article

RAS mutation status and immune microenvironment define distinct prognostic landscapes and predict chemotherapy benefit in pMMR colorectal cancer.

Frontiers in immunology - 1 Jan 2026

Wu Shigang, Li Jinbang, Chen Zhe, Liu Jihong, Luo Feng, Li Bingquan, Zeng Jun, Liu Kunping

Abstract excerpt

Purpose: The aim of this study was to define the interplay between K/N-RAS mutational status, tumor immune microenvironment (TIME), and chemotherapy response in patients with proficient mismatch repair (pMMR) colorectal cancer (CRC)-a population refractory to immunotherapy but constituting >90% of CRC cases. Methods: We retrospectively analyzed 225 patients with pMMR CRC. Multiplex immunohistochemistry was used...

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Identifiers

PMID: 42183281
DOI: 10.3389/fimmu.2026.1798858
PMCID: PMC13189948

Genes

CD163
CD4
CMTM6
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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