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Article

The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2020

Zheng Zhonghua, Li Yin, Jin Gehui, Huang Tianyi, Zou Mengsha, Duan Shiwei

Abstract excerpt

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins. ALOX12 protein plays an important role in inflammation and oxidation, while abnormal DNA methylation and genetic variants of ALOX12 are associated with various human diseases and pathological phenotypes, such as cardiovascular...

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PMID: 32540644
DOI: 10.1016/j.biopha.2020.110354

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