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Arachidonic and oleic acid exert distinct effects on the DNA methylome

18 Apr 2016

Abstract excerpt

Abnormal fatty acid metabolism and availability are landmarks of metabolic diseases, which in turn are associated with aberrant DNA methylation profiles. To understand the role of fatty acids in disease epigenetics, we sought DNA methylation profiles specifically induced by arachidonic (AA) or oleic acid (OA) in cultured cells and compared those with published profiles of normal and diseased tissues. THP-1...

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PMID: 27088456
DOI: 10.1080/15592294.2016.1161873

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