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Article

Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.

The Journal of biological chemistry - 8 Aug 2014

Hester Austin G, Murphy Robert C, Uhlson Charis J, Ivester Priscilla, Lee Tammy C, Sergeant Susan, Miller Leslie R, Howard Timothy D, Mathias Rasika A, Chilton Floyd H

Abstract excerpt

Dramatic shifts in the Western diet have led to a marked increase in the dietary intake of the n-6 polyunsaturated fatty acid (PUFA), linoleic acid (LA). Dietary LA can then be converted to arachidonic acid (ARA) utilizing three enzymatic steps. Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) and certain genetic variants within the cluster are highly...

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Identifiers

PMID: 24962583
DOI: 10.1074/jbc.M114.579557
PMCID: PMC4139254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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