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ALOX12B overexpression in the skin drives inflammasome/Th17 signaling axis to promote inflammation in the mouse model and human patients

2025-06-11

Abstract excerpt

Inflammation plays a pivotal role in the etiopathogenesis of chronic inflammatory skin diseases. However, the underlying mechanism remains unclear. Here, we employed Gene expression meta-analysis and clinical validation to dissect the global architecture of immune dysregulation responsible for inflammatory conditions in the skin. Using such approaches, we identified a gene signature comprising of ALOX12B, which is...

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Literature Corpus work
0a8d7052-eb91-5246-b11d-86d16bbe0b9a
DOI
10.1101/2025.06.09.658245
Open publication

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ALOX12B overexpression in the skin drives inflammasome/Th17 signaling axis to promote inflammation in the mouse model and human patientsDOI 10.1101/2025.06.09.658245
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