Article
The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination.
Pharmacological research - 1 Sept 2020
de Almeida Monique Marylin Alves, Pieropan Francesca, de Mattos Oliveira Larissa, Dos Santos Junior Manoelito Coelho, David Jorge Mauricio, David Juceni Pereira, da Silva Victor Diógenes A, Dos Santos Souza Cleide, Costa Silvia Lima, Butt Arthur Morgan
Abstract excerpt
Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia are activated in pathology and can have both pro- and anti-inflammatory functions. Here, we examined the effects of...
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