Article

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms

2025-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Retinal ganglion cells (RGCs) are highly compartmentalized cells, with long axons serving as the sole connection between the eye and the brain. RGC degeneration in injury and/or disease also occurs in a compartmentalized manner, with distinct injury responses in axonal and somatodendritic compartments. Thus, the goal of this study was to establish a novel microfluidic-based platform for the anal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c371b51f-365e-5867-96e1-c2ca8c1aa845
DOI: 10.1101/2025.05.02.651934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platformsDOI 10.1101/2025.05.02.651934Read

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms.Semantic proximity Read

Retinal ganglion cells harboring the OPTN(E50K) mutation exhibit neurodegenerative phenotypes when derived from hPSC-derived three dimensional retinal organoidsSemantic proximity Read

Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.Semantic proximity Read

Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axonsSemantic proximity Read

Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion CellsSemantic proximity Read

Introduced chemokine gradients guide transplanted and regenerated retinal neurons toward their natural position in the retinaSemantic proximity Read

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineeringSemantic proximity Read

Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularitySemantic proximity Read

Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit.Semantic proximity Read

Single Cell RNA Sequencing of stem cell-derived retinal ganglion cellsSemantic proximity Read

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiationSemantic proximity Read

Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studiesSemantic proximity Read