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Article

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2025

Gomes Cátia, Huang Kang-Chieh, Lavekar Sailee S, Harkin Jade, Prosser Carson G, Fang Yue, Kalem Claire, Oblak Adrian, Zhang Chi, Meyer Jason S

Abstract excerpt

Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40924455
DOI: 10.1073/pnas.2423682122
PMCID: PMC12452894

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OPTN

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