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Article

Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.

Oncogene - 1 Jul 2020

Lorenzo-Martín L Francisco, Rodríguez-Fdez Sonia, Fabbiano Salvatore, Abad Antonio, García-Macías María C, Dosil Mercedes, Cuadrado Myriam, Robles-Valero Javier, Bustelo Xosé R

Abstract excerpt

The current paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho GTPases, can be a valuable therapeutic strategy to treat Rho-dependent tumors. However, formal validation of this idea using in vivo models is still missing. In this context, it is worth remembering that many Rho GEFs can mediate both catalysis-dependent and independent responses,...

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Identifiers

PMID: 32528129
DOI: 10.1038/s41388-020-1353-x
PMCID: PMC7610363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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