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Article

Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice.

Molecular biology of the cell - 1 Mar 2007

Sauzeau Vincent, Jerkic Mirjana, López-Novoa José M, Bustelo Xosé R

Abstract excerpt

The Vav family is a group of signal transduction molecules that activate Rho/Rac GTPases during cell signaling. Experiments using knockout mice have indicated that the three Vav proteins present in mammals (Vav1, Vav2, and Vav3) are essential for proper signaling responses in hematopoietic cells. However, Vav2 and Vav3 are also highly expressed in nonhematopoietic tissues, suggesting that they may have additional...

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Identifiers

PMID: 17202406
DOI: 10.1091/mbc.e06-09-0877
PMCID: PMC1805112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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