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Article

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.

Nature communications - 16 Nov 2020

Rodríguez-Fdez Sonia, Lorenzo-Martín L Francisco, Fernández-Pisonero Isabel, Porteiro Begoña, Veyrat-Durebex Christelle, Beiroa Daniel, Al-Massadi Omar, Abad Antonio, Diéguez Carlos, Coppari Roberto, Nogueiras Rubén, Bustelo Xosé R

Abstract excerpt

Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates the signaling output of the IGF1- and insulin-stimulated phosphatidylinositol 3-kinase pathway in that tissue. Consistent with this, mice bearing a Vav2 protein with decreased catalytic activity exhibit...

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Identifiers

PMID: 33199701
DOI: 10.1038/s41467-020-19489-z
PMCID: PMC7669868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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