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Article

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

Nature - 20 Jun 2002

Malliri Angeliki, van der Kammen Rob A, Clark Kristopher, van der Valk Maarten, Michiels Frits, Collard John G

Abstract excerpt

Proteins of the Rho family control signalling pathways that regulate the actin cytoskeleton and gene transcription. In vitro studies have implicated Rho-like GTP-hydrolysing enzymes (GTPases) in cell migration, cell-cycle progression, and Ras-induced focus formation, suggesting a role for these GTPases in the formation and progression of tumours in vivo. To study this, we have generated mice lacking the...

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Identifiers

PMID: 12075356
DOI: 10.1038/nature00848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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