Article
Vav1 GEF activity is required for T cell mediated allograft rejection.
Transplant immunology - 1 Jun 2012
Haubert Dirk, Li Jianping, Saveliev Alexander, Calzascia Thomas, Sutter Esther, Metzler Barbara, Kaiser Daniel, Tybulewicz Victor L J, Weckbecker Gisbert
Abstract excerpt
The GDP exchange factor (GEF) Vav1 is a central signal transducer downstream of the T cell receptor and has been identified as a key factor for T cell activation in the context of allograft rejection. Vav1 has been shown to transduce signals both dependent and independent of its GEF function. The most promising approach to disrupt Vav1 activity by pharmacological inhibition would be to target its GEF function....
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