Article
The genomic landscape of childhood and adolescent melanoma.
The Journal of investigative dermatology - 1 Mar 2015
Lu Charles, Zhang Jinghui, Nagahawatte Panduka, Easton John, Lee Seungjae, Liu Zhifa, Ding Li, Wyczalkowski Matthew A, Valentine Marcus, Navid Fariba, Mulder Heather, Tatevossian Ruth G, Dalton James, Davenport James, Yin Zhirong, Edmonson Michael, Rusch Michael, Wu Gang, Li Yongjin, Parker Matthew, Hedlund Erin, Shurtleff Sheila, Raimondi Susana, Bhavin Vadodaria, Donald Yergeau, Mardis Elaine R, Wilson Richard K, Evans William E, Ellison David W, Pounds Stanley, Dyer Michael, Downing James R, Pappo Alberto, Bahrami Armita
Abstract excerpt
Despite remarkable advances in the genomic characterization of adult melanoma, the molecular pathogenesis of pediatric melanoma remains largely unknown. We analyzed 15 conventional melanomas (CMs), 3 melanomas arising in congenital nevi (CNMs), and 5 spitzoid melanomas (SMs), using various platforms, including whole genome or exome sequencing, the molecular inversion probe assay, and/or targeted sequencing. CMs...
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