Article
Elevated non-coding promoter mutations are associated with malignant transformation of melanocytic naevi to melanoma.
Pathology - 1 Aug 2022
Colebatch Andrew J, Paver Elizabeth C, Vergara Ismael A, Thompson John F, Long Georgina V, Wilmott James S, Scolyer Richard A
Abstract excerpt
Evolution from a benign naevus to a melanoma results principally from the stepwise accumulation of mutations. We used a custom next generation sequencing (NGS) panel targeting specific melanoma associated genes to analyse and compare differences between melanomas and their precursor naevi in coding and non-coding mutations and copy number aberrations, with a view to implementing this technique as an ancillary...
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