Article
The Genetic Evolution of Melanoma from Precursor Lesions.
The New England journal of medicine - 12 Nov 2015
Shain A Hunter, Yeh Iwei, Kovalyshyn Ivanka, Sriharan Aravindhan, Talevich Eric, Gagnon Alexander, Dummer Reinhard, North Jeffrey, Pincus Laura, Ruben Beth, Rickaby William, D'Arrigo Corrado, Robson Alistair, Bastian Boris C
Abstract excerpt
BACKGROUND: The pathogenic mutations in melanoma have been largely catalogued; however, the order of their occurrence is not known. METHODS: We sequenced 293 cancer-relevant genes in 150 areas of 37 primary melanomas and their adjacent precursor lesions. The histopathological spectrum of these areas included unequivocally benign lesions, intermediate lesions, and intraepidermal or invasive melanomas. RESULTS:...
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