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Article

Impact of age on N-methyl-N-nitrosourea induced microsatellite instability in young and old C57BL/6J mice.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 May 2020

Liu Xingchen, Liu Yihan, Cao Qi, Wu Ying, Huo Xueyun, Du Xiaoyan, Chen Zhenwen

Abstract excerpt

Age is an important factor in the evaluation of chemical toxicology. Chemical carcinogenic compounds can induce genomic mutations. However, few studies have been conducted on the association between genomic mutation frequency, such as microsatellite instability (MSI), and the age of mice treated with a nitrosourea mutagen. In the current work, we treated young (6 weeks) and old (10 months) mice with...

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Identifiers

PMID: 32522351
DOI: 10.1016/j.mrgentox.2020.503189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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