Article
Aging Increases Short, Inverted Repeat-Mediated Genomic Instability In Vivo.
Aging cell - 1 Dec 2025
Mandke Pooja, Kompella Pallavi, Wang Guliang, Vasquez Karen M
Abstract excerpt
Genomic instability is a hallmark of aging and cancer. A key contributor to genomic instability includes alternative DNA structures, such as cruciform-forming inverted repeats (IRs). Short IRs (< 100 bps) are abundant in the human genome, mutagenic, and enriched at mutation hotspots in human cancer genomes. Using an innovative mutation-reporter mouse model, we showed that short IRs are mutagenic in vivo. Further,...
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