Article
Evolutionary and immunological implications of contemporary HIV-1 variation.
British medical bulletin - 1 Jan 2001
Korber B, Gaschen B, Yusim K, Thakallapally R, Kesmir C, Detours V
Abstract excerpt
Evolutionary modelling studies indicate less than a century has passed since the most recent common ancestor of the HIV-1 pandemic strains and, in that time frame, an extraordinarily diverse viral population has developed. HIV-1 employs a multitude of schemes to generate variants: accumulation of base substitutions, insertions and deletions, addition and loss of glycosylation sites in the envelope protein, and...
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