Article

Distinct antibody-mediated selection in a narrow-source HIV-1 outbreak among Chinese former plasma donors

2017-07-24

Abstract excerpt

<h4>ABSTRACT</h4> The HIV-1 envelope protein mutates rapidly to evade recognition and killing, and is a major target of the humoral immune response and in vaccine development. Identification of common antibody epitopes for vaccine development have been complicated by large variations on both virus (different infecting founder strains) and host genetic levels. We studied HIV-1 envelope gp120 evolution in 12 Chine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69db41b1-f729-556d-b4e9-ca38d7e9a81c
DOI: 10.1101/167510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct antibody-mediated selection in a narrow-source HIV-1 outbreak among Chinese former plasma donorsDOI 10.1101/167510Read

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.Semantic proximity Read

Antibodies Targeting the Envelope of HIV-1.Semantic proximity Read

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.Semantic proximity Read

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding SiteSemantic proximity Read

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIVSemantic proximity Read

Identification of a novel broadly HIV-1-neutralizing antibody from a CRF01_AE-infected Chinese donorSemantic proximity Read

Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chainsSemantic proximity Read

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels.Semantic proximity Read

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.Semantic proximity Read

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Semantic proximity Read

Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwideSemantic proximity Read

Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencingSemantic proximity Read